• English
  • 旧版回顾
  • 教职工
  • 学校主页
  • 加入收藏
邹振兴副研究员
发布时间:2020/01/13   阅读量:

证件照

邹振兴,男,1987年生,副研究员,硕士生导师,博士/博士后。中南大学太阳集团y8722ycc(中国)搜狗百科药学实验中心副主任,湖南省药学会中药与天然药物委员会青年委员会副主任委员。2009年本科毕业于浙江海洋学院食品与药学学院医学院,2012.6和2016.6年先后获中南大学太阳集团y8722ycc(中国)搜狗百科医学硕士和医学博士学位,2016.11-2018.12在中南大学湘雅医院从事博士后研究,2019.1入职中南大学太阳集团y8722ycc(中国)搜狗百科。

近年来一直从事天然药物化学教学、科研及中药新药研发等相关工作。主要致力于药用蕨类植物(卷柏科、石松科)及内生菌化学成分多样性及生物学功能研究,初步探明了其传统功效与物质基础内在联系,以及生物学功能差异的规律,发现了多个具有显著抗肿瘤、抗炎、神经保护等活性的天然活性先导物。先后在PhytochemistryFitoterapiaChinese Chemical LettersFrontiers in Pharmacology等国际期刊发表30余篇SCI论文,现为FitoterapiaNPRCCL等国际期刊审稿人;先后获得国自青年基金,省自青年基金和中国博士后基金等资助,参与其他国家、省部级及新药研发课题15余项,申请国家发明专利1项。

研究方向:

1. 传统中药、药用植物及其内生真菌天然活性小分子化合物的发现、结构修饰以及生物学功能评价(肿瘤、神经保护、抗炎、抗菌等)

2. 中药新药及健康产品研发

课题组介绍:

http://yxy.csu.edu.cn/info/1097/3767.htm

近年主持或参与课题:

1. 国家自然科学基金面上项目,基于herquline A等天然产物生物合成的酚去芳构化生物催化体系的研究和应用,2019/01-2022/12,在研,参加

2. 国家自然科学青年基金,两种卷柏新颖黄酮类成分及BACE1抑制活性研究,2018/01-2020/12,在研,主持

3. 湖南省自然科学青年基金,石上柏新型天然BACE1抑制剂的发现与研究,2018/01-2020/12,在研,主持

4. 中国博士后基金面上项目,基于多靶点作用特征的中药石上柏抗AD药效物质基础研究,2018/01-2018/12,已结题,主持

5. 国家自然科学青年基金,DMATS家族酶催化黄酮定向异戊烯基化的方法研究及其合成应用,2018/01-2020/12,在研,参加

6. 中南大学博士后科研启动项目,基于深绿卷柏新颖黄酮类成分的抗AD新药临床前研究,2016/11-2018/11,已结题,主持

7. 湖南省自然科学基金面上项目,基于COX-2靶点的黑顶卷柏抗肿瘤作用研究,2016/01-2018/12,已结题,参加

8. 海口市应用技术研究与开发经费专项重点项目,海南石上柏新型抗肿瘤活性成分及其作用机制研究,2015/01-2017/12,已结题,参加

9. 国家自然科学基金面上项目,卷柏属植物COX-2抑制剂先导物的发现及抗肺癌作用机制研究,2014/01-2017/12,已结题,参加

代表性文章:

1. Zhenxing Zou, Guishan Tan, Qi Huang, Huihui Sun, Luqiong Huo, Wanqi Zhong, Liyun Zhao, Hongxin Liu*, Haibo Tan*. Brachyanins A-C, pinene-derived meroterpenoids and phloroglucinol derivative fromLeptospermum brachyandrum,Fitoterapia,2018, (130): 184˗189.

2. Zhenxing Zou, Pingsheng Xu, Guogang Zhang, Fei Cheng, Kai Chen, Jing Li, Weixing Zhu, Dongsheng Cao, Kangping Xu*, Guishan Tan*, Selagintriflavonoids with BACE1 inhibitory activity from the fernSelaginella doederleinii,Phytochemistry,2017, (134): 114˗121.

3. Zhenxing Zou, Kangping Xu, Pingsheng Xu, Xiaomin Li, Fei Cheng, Jing Li, Xia Yu, Dongsheng Cao, Li Dan, Wei Zeng, Guogang Zhang*, Guishan Tan*, Seladoeflavones A-F, six novel flavonoids fromSelaginella doederleinii,Fitoterapia,2017, (116): 66˗71.

4. Zhenxing Zou, Guishan Tan, Guogang Zhang, Xia Yu, Pingsheng Xu*, Kangping Xu*, New cytotoxic apigenin derivatives fromSelaginella doederleinii,Chinese Chemical Letters,2017, 28(5): 931˗934.

5. Zhenxing Zou, Pingsheng Xu, Canrong Wu, Weixing Zhu, Gangzhi Zhu, Xiaoai He, Guogang Zhang, Jianzhong Hu, Shao Liu, Wei Zeng, Kangping Xu*, Guishan Tan*, Carboxymethyl flavonoids and a chromone with antimicrobial activity fromSelaginella moellendorffiiHieron,Fitoterapia,2016, (111): 124˗129.

6. Zhenxing Zou, Kangping Xu, Fushuang Li, Hui Zou, Minzhen Liu, Qiong Zhang, Kai Yu, Lanfang Zhao, Leihong Tan,Guishan Tan*, A new pyrrole alkaloid fromSelaginella moellendorfiiHieron,Chinese Chemical Letters,2013, 24(2): 114˗116.

7. Lifei Liu, Huihui Sun, Jianbing Tan, Qi Huang, Fei Cheng, Kangping Xu,Zhenxing Zou*, Guishan Tan*, New cytotoxic biflavones fromSelaginella doederleinii,Natural Product Research,2019, online,DOI:10.1080/14786419.2019.1611813.

8. Fei Cheng, Kangping Xu, Lifei Liu, Caiping Yao, Pingsheng Xu, Gan Zhou, Dai Li, Xiaomin Li, Kai Chen,Zhenxing Zou*, Guishan Tan*, New neolignans fromSelaginella pictaand their protective effect on HT-22 cells,Fitoterapia,2018, (127): 69˗73.

9. Wei Zeng, Caiping Yao, Pingsheng Xu, Guogang Zhang, Zhaoqian Liu, Kangping Xu,Zhenxing Zou*, Guishan Tan*, A new neolignan fromSelaginella moellendorffiiHieron,Natural Product Research,2017, 19(31): 2223˗2227.

10. Qi Huang, Jianbing Tan, Xiangchang Zeng, Yaqin Wang,Zhenxing Zou*, Dongsheng Ouyang*, Lignans and phenolic constituents fromEucommia ulmoidesOliver,Natural Product Research,2019, ASAP, online, DOI:10.1080/14786419.2019.1700250.

11. Qiuzhu Dong,Zhenxing Zou, Xiaohui Jia, Xia Yu, Jing Li, Wenhao Zhou, Huihui Sun, Wei Wu, Guishan Tan, Kangping Xu*, Cytotoxic polyhydroxy serratene triterpenoids fromLycopodium complanatum,Bioorganic Chemistry,2019, (87): 373˗379.

12. Kangping Xu,Can Yang,Yuanyuan Xu,Dan Li,Shumin Bao,Zhenxing Zou,Fenghua Kang,Guishan Tan,Shu-Ming Li,Xia Yu*, Selective geranylation of biflavonoids byAspergillus terreusaromatic prenyltransferase (AtaPT),Organic & Biomolecular Chemistry,2019, ASAP, online, DOI: 10.1039/C9OB02296A.

13. Xi Chen, Pingsheng Xu,Zhenxing Zou, Yang Liu, Wenhao Zhou, Qin Ren, Dan Li, Xiaomin Li, Kangping Xu, Guishan Tan*, Sinensiols B-G, six novel neolignans fromselaginella sinensis,Fitoterapia,2019, (134): 256˗263.

14. Fei Cheng,Zhenxing Zou, Pingsheng Xu, Shuihan Zhang, Yan Zhang, Caiping Yao, Kangping Xu, Guishan Tan*, Pictalignans D-F, three new neolignan derivatives fromSelaginella picta,Natural Product Research,2019,ASAP, online,DOI:10.1080/14786419.2018.1560284.

15. Yang Liu,Jing Li,Dan Li,Xiaomin Li,Dai Li,Gan Zhou,Kangping Xu,Fenghua Kang,Zhenxing Zou,Pingsheng Xu*,Guishan Tan*, Anti-cholinesterase activities of constituents isolated fromLycopodiastrum casuarinoides,Fitoterapia,2019, (139): 104366.

16. Yinhua Deng, Ningning Wang,Zhenxing Zou, Lin Zhang, Kangping Xu, Alex F. Chen, Dongsheng Cao*, Guishan Tan*, Multi-target Screening and Experimental Validation of Natural Products fromSelaginellaPlants against Alzheimer’s Disease,Frontiers in Pharmacology,2017, (8): 539.

17. Rui Liu, Hui Zou,Zhenxing Zou, Fei Cheng, Xia Yu, Pingsheng Xu, Xiaomin Li, Dai Li, Kangping Xu*, Guishan Tan*, Two new anthraquinone derivatives and one new triarylbenzophenone analog fromSelaginella tamariscina,Natural Product Research,2018, ASAP, online,DOI:10.1080/14786419.2018.1452008.

18. Caiping Yao,Zhenxing Zou, Yan Zhang, Jing Li, Fei Cheng, Pingsheng Xu, Gan Zhou, Xiaomin Li, Kangping Xu*, Guishan Tan*, New adenine analogues and a pyrrole alkaloid fromSelaginella delicatula,Natural Product Research,2019, 14(33): 1985˗1991.

19. Rui Liu, Hui Zou, Pingsheng Xu,Zhenxing Zou, Jing Li, Fei Cheng, Ruihuan Liu, Gan Zhou, Kangping Xu*, Guishan Tan*, Uncinatic acids A-C, three new carboxylated flavonoids fromSelaginella uncinata,Chinese Chemical Letters,2017, 28(7): 1465˗1468.

20. Jing Li, Pingsheng Xu,Zhenxing Zou, Hui Zou, Hongping Long, Leihong Tan, Ruihuan Liu, Yikun Wang, Kangping Xu*, Guishan Tan*. Three new compounds from the roots ofJuglans mandshuricaMaxim.Phytochemistry Letters,2017, (20): 40˗44.

联系方式:

通讯地址:湖南省长沙市桐梓坡路172号中南大学太阳集团y8722ycc(中国)搜狗百科(孝骞楼614),邮编:410013

Tel:0731-82650395

E-mail:zouzhenxing@csu.edu.cn

上一条:康峰华副教授

下一条:李乾斌教授